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FARAFARA Cure FA

Frataxin interacts with Isu1 through a conserved tryptophan in its ß-sheet

Friedreich's ataxia is a neurodegenerative disease caused by the low expression of frataxin, a mitochondrial iron-binding protein which plays an important, but non-essential, role in the formation of iron–sulfur (Fe/S) clusters. It has been shown that Yfh1, the yeast frataxin homologue, interacts functionally and physically with Isu1, the scaffold protein on which the Fe/S clusters are assembled. The large β-sheet platform of frataxin is a good ligand candidate for this interaction. We have generated 12 yeast mutants in conserved residues of the β-sheet protruding at the surface or buried in the protein core.

Read More: Frataxin interacts with Isu1 through a conserved tryptophan in its ß-sheet

About the Author

Jen Farmer

Jen Farmer

Executive Director

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