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Friedreich's ataxia: Oxidative stress and cytoskeletal abnormalities

Friedreich's ataxia (FRDA) is an autosomal recessive disorder caused by mutations in the gene encoding frataxin, a mitochondrial protein implicated in iron metabolism. Current evidence suggests that loss of frataxin causes iron overload in tissues, and increase in free-radical production leading to oxidation and inactivation of mitochondrial respiratory chain enzymes, particularly Complexes I, II, III and aconitase.

Read More: Friedreich's ataxia: Oxidative stress and cytoskeletal abnormalities


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Jen Farmer

Jen Farmer

Executive Director

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