Accept Cookies?
Provided by OpenGlobal E-commerce

Please wait while your page loads ...


Iron-sulfur Assembly Complex Catalyzes [2Fe-2S] Clusters on ISCU2

Iron sulfur (Fe-S) clusters are essential protein cofactors for most life forms. In human mitochondria, the core Fe-S biosynthetic enzymatic complex (called SDUF) consists of NFS1, ISD11, ISCU2, and frataxin (FXN) protein components. Few mechanistic details are known for how this complex synthesizes Fe-S clusters and how these clusters are delivered to targets. Here circular dichroism and Mössbauer spectroscopies were used to reveal details of the Fe-S cluster assembly reaction on the SDUF complex. SDUF reactions generated [2Fe-2S] cluster intermediates that readily converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

Read More: The Human Iron-Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 that can be Transferred to Acceptor Molecules.

About the Author

Jen Farmer

Jen Farmer

Chief Executive Officer


Family B.jpg


Archived in
  Scientific News



Tagged in
FARA Scientific News

Site Map     Privacy Policy     Service Terms     Log-in     Contact     Charity Navigator