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FARAFARA Cure FA

Large-scale expansions of Friedreich's ataxia GAA repeats in yeast

Large-scale expansions of DNA repeats are implicated in numerous hereditary disorders in humans. We describe a yeast experimental system to analyze large-scale expansions of triplet GAA repeats responsible for the human disease Friedreich's ataxia. When GAA repeats were placed into an intron of the chimeric URA3 gene, their expansions caused gene inactivation, which was detected on the selective media.

Read More: Large-scale expansions of Friedreich's ataxia GAA repeats in yeast


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Jen Farmer

Jen Farmer

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