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FARAFARA Cure FA

Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly

Iron-sulfur (Fe-S) cluster-containing proteins are essential components of cells. In eukaryotes, Fe-S clusters are synthesized by the mitochondrial iron-sulfur cluster (ISC) machinery and the cytosolic iron-sulfur assembly (CIA) system. In the mammalian ISC machinery, preassembly of the Fe-S cluster on the scaffold protein (ISCU) involves a cysteine desulfurase complex (NFS1/ISD11) and frataxin (FXN), the protein deficient in Friedreich's ataxia.

Read More: Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly


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Jen Farmer

Jen Farmer

Executive Director

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