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Newcastle Imaging Study

Developing a new tool to measure how nerves are affected in FA

Ages: 10-50

Location: Newcastle University, UK

Details: The main aim of this research is to allow us to develop a more accurate method of monitoring the progression of your condition. This will then allow us to work out whether a particular treatment is slowing the progression of the disease in future clinical trials. This study involves a combination of clinical assessments and non-invasive neurophysiological tests, a blood test and a very small skin sample.

Please see the study flyer below and contact Dr. Vandy Dhawan at 0191 2086897 or with any questions.

Shire's SHP622 Phase 1 Study (formerly VP-20629)

Safety and Pharmacology Study of VP 20629 (now called SHP622) in Adults With FA

Ages: 18-45

Locations: Children's Hospital of Philadephia (CHOP), Emory, University of South Florida, University of Iowa, UCLA

Details: This is a Phase 1 study sponsored by Shire (formerly initiated by ViroPharma) designed to evaluate dosage and safety of VP20629, a naturally occurring small molecular weight drug compound that can prevent oxidative stress to improve mitochondrial function. Participation in this study requires both outpatient and inpatient visits. Subjects in the second arm need to stay in the hospital for 10 days. In the second arm, subjects will receive multiple doses of VP 20629 (300 mg, 600 mg, or 900 mg total daily dose) or placebo. VP20629 or placebo will be administered every 8 hours for 7 days with a single morning dose on Day 8.

Cardiovascular Effects of Acetyl-L-Carnitine

Description: An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's Ataxia.
The purpose of this study is to learn how treatment with acetyl-L-carnitine (ALCAR) will affect the hearts of patients with Friedreich's Ataxia as well as how it may affect other symptoms of Friedreich's Ataxia such as difficulties with balance, walking, or upper arm function. There are 11 visits to the research clinic at the University of South Florida Morsani Center for Advanced Health Care. Study related procedures and medication will be provided by the sponsor.

Key Criteria: Ages 18-80 years

Location: University of South Florida -

Please review the study flyer below, and contact the Study Coordinator with any questions.

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