Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function. The compounds, having a different redox core but the same side chain as idebenone, exhibited a range of potencies, reflecting differences in their structures.
Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection
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