Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans

Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox indicates that cellular adaptation to partial mitochondrial stress can induce beneficial responses, but how this is achieved is largely unknown.

Read More: Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans