HSC20 interacts with Frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis

Friedreich's ataxia is a neurodegenerative disorder caused by mutations in the frataxin gene that produces a predominantly mitochondrial protein whose primary function appears to be mitochondrial iron-sulfur cluster (ISC) biosynthesis. Previously we demonstrated that frataxin interacts with multiple components of the mammalian ISC assembly machinery.

HSC20 interacts with Frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis